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Physical or mental tiredness following a prolonged period of hard work.  Muscle fatigue resulting from hard exercise is caused by a buildup of lactic acid.  Lactic acid is produced in muscles (as an end product of the breakdown of glycogen to produce energy), and builds up when there is an insufficient supply of oxygen.  The muscle is unable to work properly until a period of rest and restored oxygen supply enables the lactic acid to be removed.




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